Antibiotics v2.0: computational and synthetic biology approaches to combat antibiotic resistance

Synthetic Biology Approaches to Combat Antibiotic Resistant Bacteria

Synthetic biology (SB) is an innovative and emerging field, representing a confluence of science and engineering. It aims to (re)-design biological parts, devices and systems while applying engineering principles for useful applications. Valuable insight gained on the functions of biological systems will further improve the design capacity. The advance of SB is expected to provide solutions to ...

Strategies to Combat Antibiotic Resistance

Antibiotics and Antibiotic Resistance

A AAC(60)-Ib-cr, 185 ACHN-975 clinical studies, 163–164 medicinal chemistry, 166 structure, 162 AcrAB-TolC, 180 AcrD, 236 AdeRS, 257 AFN-1252 mechanism of action, 148, 153 resistance, 153 structure, 149 AIM-1, 74 Amicoumacin A, 222 Amikacin indications, 240 structure, 230 synthesis, 4 Aminoglycosides. See also specific drugs historical perspective, 229–230 indications, 239–241 mechanism of acti...

Nanoantibiotics: Future nanotechnologies to combat antibiotic resistance.

The discovery of antibiotics was hailed as a historic breakthrough for the human race in the fight against bacterial and malignant infections. However, in a very short time, owing to their acute and aggressive nature, bacteria have developed resistance against antibiotics and other chemotherapeutics agents. Potentially, this situation could again result in bacterial infection outbreaks. Metal a...

Development of botanicals to combat antibiotic resistance

The discovery of antibiotics in the previous century lead to reduction in mortality and morbidity due to infectious diseases but their inappropriate and irrational use has resulted in emergence of resistant microbial populations. Alteration of target sites, active efflux of drugs and enzymatic degradations are the strategies employed by the pathogenic bacteria to develop intrinsic resistance to...