منابع مشابه
Relevance of microbial coculture fermentations in biotechnology.
The purpose of this article is to review coculture fermentations in industrial biotechnology. Examples for the advantageous utilization of cocultures instead of single cultivations include the production of bulk chemicals, enzymes, food additives, antimicrobial substances and microbial fuel cells. Coculture fermentations may result in increased yield, improved control of product qualities and t...
متن کاملMicrobial transformations of antibiotics.
In spite of their unusual molecular structures and seemingly high degree of biological recalcitrance, many antibiotics have been shown to be susceptible to microbial attack. Among the types of changes brought about by microbial systems are: (i) acylation; (ii) phosphorylation; (iii) adenylylation and ribonucleotide formation; (iv) hydrolysis; (v) oxidation; (vi) suiph oxidation; (vii) reduction...
متن کاملMicrobial Transformation of Antibiotics: Phosphorylation
Addition of clindamycin to whole-cell cultures of Streptomyces coelicolor MUller resulted in the loss of in vitro activity against organisms sensitive to clindamycin. Incubation of such culture filtrates with alkaline phosphatase generated a biologically active material identified as clindamycin. Fermentation broths containing inactivated clindamycin yielded clindamycin 3-phosphate, the structu...
متن کاملMicrobial Degradation of Sulfonamide Antibiotics
Certain microbes can transform antibiotics in the environment. However, little is known about the identity of these microbes and their antibiotic biotransformation processes. The objectives of this study were to (1) isolate bacterial strains capable of transforming antibiotics, (2) determine the biotransformation kinetics of antibiotics, (3) characterize the effects of background carbons on the...
متن کاملAntibiotics: Conflict and Communication in Microbial Communities Antibiotics mediate species interactions in natural habitats, affecting the dynamics of microbial coevolution
The discovery that microbes produce antibiotic compounds that kill or inhibit other microbes revolutionized modern medicine by offering a means to treat microbial infections. Thus, the “golden age” of antibiotic discovery began when hundreds of antibiotics from diverse microbial genera were characterized for their effıcacy in controlling pathogens and the infections they cause. When used at sub...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2016
ISSN: 0021-8820,1881-1469
DOI: 10.1038/ja.2016.127