Antibiotic Treatment of Anthrax Infection in Mice

Antibiotic treatment of anthrax infection in mice.

Quantitative measurements of mean time to death, percentage of survivors, and viable cell populations in the whole body were employed to determine the effects of penicillin, dihydrostreptomycin, chlortetracycline, oxytetracycline, chloramphenicol, and antiserum on the course of anthrax infection in mice. By all parameters tested, penicillin and dihydrostreptomycin were most effective in the tre...

Effective antiprotease-antibiotic treatment of experimental anthrax

BACKGROUND Inhalation anthrax is characterized by a systemic spread of the challenge agent, Bacillus anthracis. It causes severe damage, including multiple hemorrhagic lesions, to host tissues and organs. It is widely believed that anthrax lethal toxin secreted by proliferating bacteria is a major cause of death, however, the pathology of intoxication in experimental animals is drastically diff...

Reducing Anthrax Infection in Man through Animal Vaccination in Iran

A Biomathematical Model of Pneumococcal Lung Infection and Antibiotic Treatment in Mice

Pneumonia is considered to be one of the leading causes of death worldwide. The outcome depends on both, proper antibiotic treatment and the effectivity of the immune response of the host. However, due to the complexity of the immunologic cascade initiated during infection, the latter cannot be predicted easily. We construct a biomathematical model of the murine immune response during infection...

Treatment of anthrax in children.

Anthrax has been described since biblical times. It was the first disease proved to be caused by an identified bacterial agent, the Bacillus anthracis. In man, the disease occurs in a cutaneous form as a malignant pustule, in a pulmonary form as wool sorters' disease, and very rarely in an intestinal form. Although the incidence of anthrax is rare in many parts of the world, it still remains en...