Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides

Antimicrobial Drug Use and Antibiotic-Resistant Bacteria

To the Editor: The article by Harris et al., published in the August 2007 issue of Emerging Infectious Diseases, examined the risk factors for selecting extended-spectrum β-lactamase–producing Enterobacteriaceae in intensive-care patients and found that exposure to piperacillin/tazobactam and vancomycin were independent risk factors (1). Although antimicrobial drug use has been historically lin...

Collateral sensitivity to methotrexate in cells resistant to adriamycin.

Chinese hamster ovary (CHO) cells, maintained and treated in log-phase growth, are extremely sensitive to Adniamycin but are very resistant to methotrexate-induced cell killing. The survival response to Adniamycin is biphasic, with the sensitive population showing a D0 of 0.08 pg/mI for 1 hr, while essen tially no cell killing is produced by methotrexate treatments of up to 500 @.tg/mI for eith...

Impacts of Antibiotic-Resistant Bacteria

Susceptibility of Colistin-Resistant, Gram-Negative Bacteria to Antimicrobial Peptides and Ceragenins

The susceptibility of colistin-resistant clinical isolates of Klebsiella pneumoniae to ceragenins and antimicrobial peptides (AMPs) suggests that there is little to no cross-resistance between colistin and ceragenins/AMPs and that lipid A modifications are found in bacteria with modest changes in susceptibility to ceragenins and with high levels of resistance to colistin. These results suggest ...

Insect antimicrobial peptides show potentiating functional interactions against Gram-negative bacteria

Antimicrobial peptides (AMPs) and proteins are important components of innate immunity against pathogens in insects. The production of AMPs is costly owing to resource-based trade-offs, and strategies maximizing the efficacy of AMPs at low concentrations are therefore likely to be advantageous. Here, we show the potentiating functional interaction of co-occurring insect AMPs (the bumblebee line...