Antibiotic Action
نویسندگان
چکیده
منابع مشابه
The complexities of antibiotic action
Antibiotics are arguably the most successful medicine on the planet, but the one under huge threat from antibiotic resistance in the face of diminishing new antimicrobial discovery efforts (Hancock, 2007). One of the great hopes for discovering new antibiotics arose when whole-genome sequencing came of age in 1995 with the decoding of the Haemophilus influenzae genome, followed rapidly by those...
متن کاملProteomic approach to understanding antibiotic action.
We have used proteomic technology to elucidate the complex cellular responses of Bacillus subtilis to antimicrobial compounds belonging to classical and emerging antibiotic classes. We established on two-dimensional gels a comprehensive database of cytoplasmic proteins with pIs covering a range of 4 to 7 that were synthesized during treatment with antibiotics or agents known to cause generalize...
متن کاملMode of action of antibiotic U-20,661.
Antibiotic U-20,661 was shown to inhibit predominantly deoxyribonucleic acid (DNA)-directed ribonucleic acid (RNA) synthesis by binding to the double-stranded DNA template. Specific binding to DNA was verified by difference spectroscopy, reversal of the RNA polymerase inhibitory effect by increasing concentrations of DNA template, and by moderately increasing the melting temperature of double-s...
متن کاملMode of action of antibiotic U-24,544.
Antibiotic U-24,544, a new antibacterial agent, was found to be an effective uncoupler of phosphorylation associated with the oxidation of glutamate and succinate in rat liver mitochondria. Respiration was inhibited during glutamate oxidation but not during succinate oxidation. In a medium deficient in inorganic phosphate, the agent showed slight stimulation of mitochondrial glutamate oxidation...
متن کاملAntibiotic action of Solanum incanum Linnaeus.
The fruits of Solanum incanum Linnaeus are extensively used in Kenya for the treatment of cutaneous mycotic infections and other pathological conditions. The therapeutic activity of the berries has been attributed to their content of solanine and related glycoalkaloids, which are saponins and cytostatic poisons. In the present study, however, a simpler more potent antimicrobial substance with a...
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ژورنال
عنوان ژورنال: Nature
سال: 1973
ISSN: 0028-0836,1476-4687
DOI: 10.1038/243363c0