منابع مشابه
Antibiofilm peptides against oral biofilms
The oral cavity is a major entry point for bacteria and other microorganisms. Oral biofilms are formed by mixed communities of microorganisms embedded in an exopolysaccharide matrix. Biofilms forming on dental hard or soft tissue are the major cause of caries and endodontic and periodontal disease. Human oral biofilms exhibit high resistance to antimicrobial agents. Antibiofilm peptides constit...
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In the history of human medicine, antibiotics represent epochal examples of medical progress. However, with an approaching antibiotic crisis due to the emergence and extensive spread of antimicrobial resistance among bacterial agents, as well as to increasing number of patients with chronic and recalcitrant bacterial biofilm-associated infections, the naturally occurring molecules may become ne...
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Streptococcus mutans is a key etiological agent in the formation of dental caries. The major virulence factor is its ability to form biofilms. Inhibition of S. mutans biofilms offers therapeutic prospects for the treatment and the prevention of dental caries. In this study, 14 analogs of makaluvamine, a marine alkaloid, were evaluated for their antibacterial activity against S. mutans and for t...
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Polysaccharides are polymers of carbohydrates with an enormous structural diversity, from long linear repetition of the same monomer to highly branched structures of different sugars. This high structural diversity reflects the functional diversity of these molecules. There are two types of polysaccharides, storage polysaccharides (i.e. glycogen) and structural polysaccharides, which are normal...
متن کاملAntibiofilm activity of dual-function Tail tubular
12 Background: Dual function tail tubular proteins (TTP) from lytic bacteriophage are novel 13 interesting group of biologically active enzymes possessing antibiofilm activity. Surprisingly, apart 14 from their structural function, they are also polysaccharide hydrolyzes destroying bacterial 15 extracellular components. One of the representatives of this group is TTPB from KP32 phage. Here, 16 ...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2002
ISSN: 1074-5521
DOI: 10.1016/s1074-5521(02)00192-8