Antibacterial peptides in stimulated human granulocytes

Antibacterial effect of microvesicles released from human neutrophilic granulocytes.

Cell-derived vesicles represent a recently discovered mechanism for intercellular communication. We investigated their potential role in interaction of microbes with host organisms. We provide evidence that different stimuli induced isolated neutrophilic granulocytes to release microvesicles with different biologic properties. Only opsonized particles initiated the formation of microvesicles th...

Antibacterial Peptides: A Review

Antibacterial peptides (APs), small molecules composed of less than fifty amino acid residues, are important components of the innate immune system. APs are produced by almost all living organisms in a defense strategy against invading pathogens. APs can be divided into many subtypes following different criteria: origin, size, structure, mechanism of action, etc... Despite their great diversity...

Cathelicidin Family of Antibacterial Peptides

Antibacterial peptides from thermophilic bacteria

It is becoming interestingly apparent that innovations of the classical antibiotics are not effective, that induces need for novel drugs. Peptide antibiotics exhibit a group of secondary metabolites with hydrophobic and cyclic structures containing d-amino acidc like compounds with more resistant to proteolytic degradation. Bacterial peptides can possess bactericidal, fungicidal, metal chelatin...

Chemotactic for Human Granulocytes

A biologically active glutathione adduct of the eicosanoid 5-oxo-eicosatetraenoic acid has been observed as a product formed within the murine peritoneal macrophage. This five-oxo glutathione adduct (FOG 7 ) was structurally characterized using electrospray tandem mass spectrometry as a 1,4 Michael addition product 5-oxo-7-glutathionyl-8,11,14-eicosatrienoic acid. FOG 7 was found to be highly p...