ANTIBACTERIAL ACTIVITIES OF LEAF METHANOLIC EXTRACTS OF Leptadenia hastata AGAINST Escherichia coli CLINICAL ISOLATE

The research aims at potential activities of leaf methanolic extracts Leptadenia hastata against clinical Escherichia coli and extraction, phytochemicals biochemical tests to the plant organism. is Gram negative, non-capsulated, bacillus, clinically important bacteria mostly isolated capable cause gastro enteritis, urinary tract infections, diarrhea among others. L. a climbing shrub that produces flexible latex which become woody base. Potential were observed. sampled, Phyto-chemically screened using methanol processed Di-MethylSulfurOxide (DMSO). Clinical Bacterial Isolates collected from Murtala Muhammed Specialist Hospital Kano, Kano State, Nigeria, investigated for E. Gram’s staining technique some procedure confirmation. isolates. Four (4) found tested different concentrations 125, 250, 500 1000 mg/mL respectively. Activity was observed directly proportional concentrations, where Minimum inhibitory concentration (MIC) bactericidal (MBC) accordingly. may lead effective drug development address its pathogenicity, Public Health benefit. It recommended further should be carried out determine bioactive components leaf, toxicity level Molecular characterization isolate (E. coli).