Anti-Zika virus RNAi in neural progenitor cells
نویسندگان
چکیده
منابع مشابه
Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells
Zika virus (ZIKV) infection has been associated with severe complications both in the developing and adult nervous system. To investigate the deleterious effects of ZIKV infection, we used human neural progenitor cells (NPC), derived from induced pluripotent stem cells (iPSC). We found that NPC are highly susceptible to ZIKV and the infection results in cell death. ZIKV infection led to a marke...
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Recent Zika virus (ZIKV) infections have been associated with a range of neurological complications, in particular congenital microcephaly. Human neural progenitor cells (hNPCs) are thought to play an important role in the pathogenesis of microcephaly, and experimental ZIKV infection of hNPCs has been shown to induce cell death. However, the infection efficiency and rate of cell death have vari...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2019
ISSN: 1001-0602,1748-7838
DOI: 10.1038/s41422-019-0158-3