Anti-vibriosis bioactive molecules from Arctic Penicillium sp. Z2230

Abstract Vibrio species ( sp.) is a class of Gram-negative aquatic bacteria that causes vibriosis in aquaculture, which have resulted big economic losses. Utilization antibiotics against has brought concerns on antibiotic resistance, and it essential to explore potential alternatives. In this study, seven compounds (compounds 1 – 7 ) were isolated from the Arctic endophytic fungus Penicillium sp. Z2230, among 3 , 4 5 showed anti- activity. The structures comprehensively elucidated, antibacterial mechanism was explored by molecular docking. results suggested activity could come inhibition bacterial peptide deformylase (PDF). This study discovered three -derived be lead molecules for developing novel agents, identified PDF as promising target. It also expanded bioactive diversity polar fungi showing an example secondary metabolites microbe good source natural medicine. Graphical