Anti-ulcer and hematological properties of virgin coconut oil (VCO) against indomethacin-induced gastric ulcer in experimental rats
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چکیده
منابع مشابه
Gastroprotective effect of sodium hydrosulfide against indomethacin-induced gastric ulcer in diabetic rats
Introduction: The incidence rate of gastric erosions and ulcers in diabetic patients are higher due to failure of mucosal antioxidant defense and maintain enough blood flow. The present study evaluated the gastro-protective effect of sodium hydrosulfide (NaHS) against indomethacin-induced gastric lesions in diabetic rats. Methods: In order to test anti-ulcer activity of NaHS against indomet...
متن کاملEvaluation of Anti-ulcer Activity of Echinops Persicus on Experimental Gastric Ulcer Models in Rats
Extract of Echinops persicus is traditionally used for a long time in Iran for treatment of cough and constipation. This extract is produced by activity of bug (Situphilus spp.) on the plant. We documented its anti-tussive effect in rats in our previous study. The aim of this study was to assess the anti-ulcer effect of Echinops persicus in an animal model. In this study we evaluated anti-ulcer...
متن کاملAnti-ulcerogenic Effect of Genistein against Indomethacin-induced Gastric Ulcer in Rats
Objectives: Free radicals generation, inflammation, and nitric oxide (NO) modulation are involved in indomethacin (IND)-induced gastric ulcers. Most of the drugs used for the treatment of gastric ulcer have various side effects. Genistein (GEN), the natural isoflavones isolated from soya bean has an antioxidant, anti-inflammatory, and NO modulating activity. These properties could make GEN a pr...
متن کاملA Direct Comparison of Anti-ulcer Effects of Coenzyme Q10 and Vitamin C on Indomethacin-induced Gastric Ulcer in Rat: A Controlled Experimental Study
Introduction: Indomethacin increases generation of mitochondrial reactive oxygen species (ROS) which have a crucial role in the indomethacin-induced gastric ulcer. Coenzyme Q10 has an antioxidant activity on mitochondria and cell membranes and protects lipids from oxidation and is essential for stabilizing biological membranes. Superoxide dismutase (SOD) acts as one of the defense mechanisms ag...
متن کاملAntiulcer effects of Zataria multiflora Boiss. on indomethacin-induced gastric ulcer in rats
Objective: Zataria multiflora has been reported to have several medicinal properties including antioxidant, antibacterial, antispasmodic, and expectorant activities. This study aimed to investigate the effect of Z. multiflora hydro-alcoholic extract (ZMHE) on peptic ulcer caused by indomethacin in rats. Materials and Methods: ZMHE was prepared by maceration, condensed by rotary evaporator and ...
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ژورنال
عنوان ژورنال: African Journal of Pharmacy and Pharmacology
سال: 2018
ISSN: 1996-0816
DOI: 10.5897/ajpp2018.4946.