Anti-ulcer Activity of Crude Extract and Fractions of Acanthus montanus (Nees) T. Anderson on Indomethacin-Induced Ulcer

Peptic ulcer disease has remained a global threat due to several complications such as perforation, gastrointestinal obstruction and organ penetration associated with the disease. This study evaluated phytochemical composition anti-ulcer activity of crude extract fractions Acanthus montanus on an indomethacin-induced in mouse model. The plant was extracted using cold maceration methanol fractionated solvents varying polarities into their corresponding fractions. screening conducted standard procedure. acute toxicity test employed Lorke’s method method. revealed abundance tannins, saponins, steroids/terpenoids flavonoids An showed that is safe even at high dose 5000 mg/kg. A. elicited dose-dependent against peptic strong curative indices 79, 93, 71% for 400 mg/kg doses aqueous, n-hexane respectively compared 42% index control. There healing eliciting higher than 200 doses. aqueous fraction ofmethanol extract, significantly different (p<0.05) from those controls. rich presence biologically active constituents antiulcerogenic properties supports its use ethnomedicine.&nbsp