Anti-TNF and Crohns Disease: When Should We Stop?

Anti-TNF and Crohn's disease: when should we stop?

When to stop anti-TNF therapy in Crohn's disease (CD)? This is a very important question both for patients and physicians. There is no published evidence to clearly and definitely answer this question. However data on natural history of CD, long term safety of biologics, outcome after immunosuppressors (IS) cessation and some preliminary studies on biologics cessation may help us to discuss thi...

When should we stop resuscitation efforts after blunt traumatic arrest?

In a recent issue of Injury, Galluccio et al. presented a stimulating case 8 which should provoke us to reconsider the boundaries of what is possible after cardiac arrest secondary to apparent blunt trauma. This report follows a previous study in Injury reporting survival after cardiac arrest after trauma. 24 Their patient, a 42-year-old male driver, crashed his vehicle at 60 km/h and was found...

When should we use TNF antagonists in children with rheumatic disease?

When should patients with Alzheimer disease stop driving?

Deniz Erten-Lyons, MD Patients with Alzheimer disease (AD) usually have problems with memory. During their illness, they may also start having problems with making good decisions. They may begin having difficulty with interpreting things that they see and may react slower. They may have trouble following directions and may get lost. These abilities are all necessary for safe driving. Therefore,...

Are we giving biologics too much time? When should we stop treatment?

The optimal duration of biological treatment, particularly anti-TNF, in inflammatory bowel disease (IBD) is a very important question both for patients and physicians. There is no published evidence to clearly and definitely answer this question. However data on natural history of IBD, long term safety of biologics, immunosuppressors (IS) cessation and some preliminary studies on biologics cess...