Anti oxidative/neuro-inflammation properties of Withania somnifera root extract on rotenone induced stress in rat brain

Parkinson's disease (PD) is a neurological condition that worsens with age (i.e., 1% of people over 65) no permanent cure. Hence, finding disease-modifying agent fewer undesirable side effects urgently needed. pathology results in the degeneration dopaminergic (DAergic) neurons by accumulating lewy bodies, alpha-synuclein (-syn), lowering anti-oxidants, increasing neuronal inflammation, and altering neuron shape. A well-researched natural substance called withania somnifera (WS) has potent anti-oxidative, anti-inflammatory, anti-neurodegenerative impact. WS, sometimes as Indian Ginseng, subtropical undershrub Solanaceae family together Ashwagandha. In current work, EWSR's anti-inflammatory neuroprotective efficacy was assessed relation to rotenone-induced oxidative stress LPO, CAT, SOD & GSH), microglial activation, neurodegeneration rotenone rat PD model. ROT-induced brains, EWSR therapy resulted considerable decrease LPO increased levels antioxidants SOD, GSH. Furthermore, our research showed intraperitoneal treatment (40 mg/kg) rats reduced activation loss substantia nigra (SN) hippocampus caused neurotoxicity. Based on observations, can be considered an excellent source for neuroprotection, due its significant anti-microglial properties when administered individually combination known compounds (Doxycycline Ellagic acids). But, further required before replacing treatments phytochemical treatments.