Anti oxidative activities of aqueous and ethanolic extracts of stem barks from trichilia emetica in albinos rats

: In chronic diseases in general and diabetes mellitus hypertension particular, there is an important imbalance between antioxidant defenses the production of free radicals due to reactive oxygen species, thus leading increase oxidant stress markers. Therefore, this study was designed evaluate antioxydative protective effects aqueous ethanolic extracts trichilia emetica stem bark albinos rats with alloxan-induced or adrenaline-induced hypertensive. Two different batches were used distinctly including a control one 3 for each batch so test group 21 rats. Diabetes induced by injecting Alloxane® intraperitoneally 7 days. Hypertension Adrenaline® eight days we visitech BP 2000 tools measure arterial pressure. The Trichilia prepared obtained mixture homogenized using magnetic stirrer 24 hours. Rats received above-mentioned orally at doses 100 200 mg/kg bw 6 Aorta heart activities catalase significantly increased. This same trend observed superoxide dismutase activity together increasing AChE catalytic vessels. Treatment seven emetic nifedipineproduced significant decrease antioxidative markers SOD as well. action slightly above nifedipineone administrated 10 20 bw. For treated diastabolwe registered MDA GSH concentration. Our results showed that have potential reduce rate species alloxane-induced However, further large studies are needed investigate specific particularity could justify these activities.