منابع مشابه
Immunomodulatory and anti-inflammatory activity of selected osthole derivatives.
From osthole [7-methoxy-8-(3-methyl-but-2-enyl)-chromen-2-one] (I), obtained by selective extraction of Peucedanum ostruthium (L.) W. Koch roots, ostholic acid (II) was synthetized as a result of its oxidation with chromium trioxide. From ostholic acid, through its chloride, four amides were obtained: the morpholide 1, the p-chloro-benzylamide 2, the piperidine 3 and the N-methyl-piperazide 4. ...
متن کاملNeuroprotection of Osthole against Cerebral Ischemia/Reperfusion Injury through an Anti-apoptotic Pathway in Rats.
Cerebral ischemia/reperfusion (I/R) injury is a major cause of acute brain injury. The pathogenetic mechanisms underlying I/R injury involve apoptosis, inflammation and oxidative stress. Osthole-a plant coumarin compound-has been reported to protect against focal cerebral I/R-induced injury in rats. However, the mechanism remains unknown. Here we hypothesize that osthole acts through inhibition...
متن کاملOsthole inhibits bone metastasis of breast cancer
Bone is one of the most common sites for breast cancer metastasis, which greatly contributes to patient morbidity and mortality. Osthole, a major extract from Cnidium monnieri (L.), exhibits many biological and pharmacological activities, however, its potential as a therapeutic agent in the treatment of breast cancer bone metastases remain poorly understood. In this study, we set out to investi...
متن کاملAnti-Cancer Activity of an Osthole Derivative, NBM-T-BMX-OS01: Targeting Vascular Endothelial Growth Factor Receptor Signaling and Angiogenesis
Angiogenesis occurs during tissue growth, development and wound healing. It is also required for tumor progression and represents a rational target for therapeutic intervention. NBM-T-BMX-OS01 (BMX), derived from the semisynthesis of osthole, an active ingredient isolated from Chinese herb Cnidium monnieri (L.) Cuss., was recently shown to enhance learning and memory in rats. In this study, we ...
متن کاملPotential of Osthole as Alternative Medicine in Alzheimer Disease
Alzheimer disease (AD) is a complex neurodegenerative disease that leads to the decline in the cognition in elderly people (>65 years of age). Deposition of senile plaques (of amyloid β) and neurofibrillary tangles (of hyperphosphorylated tau) are the typical hallmarks of the disease. AD significantly contributes to the worldwide dementia, which is 46.8 million in 2015 and estimated to 131.5 mi...
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ژورنال
عنوان ژورنال: Pharmacognosy Research
سال: 2016
ISSN: 0974-8490
DOI: 10.4103/0974-8490.178650