Anti-influenza viral effects of novel nuclear export inhibitors from Valerianae Radix and <i>Alpinia galanga </i>
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چکیده
منابع مشابه
Anti-influenza viral effects of novel nuclear export inhibitors from Valerianae Radix and Alpinia galanga.
Many pathogenic viruses, such as the influenza virus and the Human Immunodeficiency Virus (HIV)-1, are a threat to humans, thus leading to thousands of deaths annually. The development of antiviral drugs is urgent, and it is an essential strategy for the suppression of these infectious diseases. However, regardless of the rapid emergence of many infectious diseases, the development of novel ant...
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The protein kinase inhibitor H7 blocks influenza virus replication, inhibits production of the matrix protein (M1), and leads to a retention of the viral ribonucleoproteins (vRNPs) in the nucleus at late times of infection (K. Martin and A. Helenius, Cell 67:117-130, 1991). We show here that production of assembled vRNPs occurs normally in H7-treated cells, and we have used H7 as a biochemical ...
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ژورنال
عنوان ژورنال: Drug Discoveries & Therapeutics
سال: 2011
ISSN: 1881-7831,1881-784X
DOI: 10.5582/ddt.v5.1.26