Anti-inflammatory effects of IL-4 and IL-10 on Human Polymorphonuclear Leukocytes
نویسندگان
چکیده
منابع مشابه
Anti-inflammatory effects of IL-4 and IL-10 on human polymorphonuclear leukocytes.
Inflammatory responses are strictly regulated by coordination of pro-inflammatory and anti-inflammatory mediators. Interleukin-4 (IL-4) and interleukin-10 (IL-10) have typically the biologic anti-inflammatory effects on monocytes, but uncertain effects on polymorphonuclear leukocytes (PMNs). The PMNs are the first line of cellular response for host defense during acute inflammation. To modify h...
متن کاملRegulation by anti-inflammatory cytokines (IL-4, IL-10, IL-13, TGFβ)of interleukin-8 production by LPS- and/ or TNFα-activated human polymorphonuclear cells
The capacity to down-regulate the production of IL-8 by LPS-activated human polymorphonuclear cells (PMN) has been demonstrated for IL-4, IL-10, and TGFbeta. We compared their relative capacities and further extended this property to IL-13. We report a great heterogeneity among individuals related to the responsiveness of PMN to the IL-4 and IL-13 inhibitory effects while their response to the ...
متن کاملAnti-inflammatory cytokines (IL-4, IL-10, IL-13) in plasma during mesenteric infarction.
We have recently reported that excessive synthesis of proinflammatory cytokines such as interleukin-6 (IL6) and IL-8 may play a role in the pathogenesis of mesenteric infarction. IL-4, IL-10 and IL-13 are classified as anti-inflammatory cytokines because they reduce the secretion of proinflammatory cytokines by stimulated monocytes/macrophage. During several inflammatory states anti-inflammator...
متن کاملInterleukin 10 (IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leukocytes by delaying mRNA degradation
Polymorphonuclear leukocytes (PMN) have been identified as cells capable of producing a number of pro- and antiinflammatory cytokines in response to specific agonists. Previously, we showed that tumor necrosis factor (TNF), interleukin-1 beta (IL-1 beta), and IL-8, are produced by PMN after stimulation with agonists, such as lipopolysaccharide (LPS). In this study, we demonstrate that LPS is al...
متن کاملContrasting effects of IL-4, IL-10 and corticosteroids on RANTES production by human monocytes.
RANTES is a chemokine produced in delayed-type hypersensitivity (DTH) and allergic reactions, in which it may contribute to the recruitment of immune cells. Macrophages participate in the cellular infiltration in both conditions and they represent a potent source of RANTES. To understand the regulation of RANTES production by human monocytes, we analyzed the effect of cytokines and of corticost...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Korean Medical Science
سال: 2002
ISSN: 1011-8934,1598-6357
DOI: 10.3346/jkms.2002.17.1.7