Anti-hypertensive and cardioprotective effects of a novel apitherapy formulation via upregulation of peroxisome proliferator-activated receptor-α and -γ in spontaneous hypertensive rats
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چکیده
منابع مشابه
Antihypertensive effects of peroxisome proliferator-activated receptor-β activation in spontaneously hypertensive rats.
Activation of nuclear hormone receptor peroxisome proliferator-activated receptor β/δ (PPARβ) has been shown to improve insulin resistance and plasma high-density lipoprotein levels, but nothing is known about its effects in genetic hypertension. We studied whether the PPARβ agonist GW0742 might exert antihypertensive effects in spontaneously hypertensive rats (SHRs). The rats were divided into...
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متن کاملIncreased Expression of Peroxisome Proliferator-Activated Receptor-a and -g in Blood Vessels of Spontaneously Hypertensive Rats
Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-activated transcription factors that include PPAR-a, PPAR-g, and PPAR-d. We hypothesized that PPAR expression in blood vessels could be reduced in hypertension to result in increased vascular growth and reduced apoptosis. We investigated the abundance of PPAR-a and PPAR-g in aorta and mesenteric arteries from young (6-we...
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ژورنال
عنوان ژورنال: Saudi Journal of Biological Sciences
سال: 2018
ISSN: 1319-562X
DOI: 10.1016/j.sjbs.2017.10.010