منابع مشابه
Estrogens as Antioxidant Modulators in Human Fertility
Among treatments proposed for idiopathic male infertility, antiestrogens, like tamoxifen, play a possible role. On the other hand, oxidative stress is a mechanism well recognized for deleterious effects on spermatozoa function. After reviewing the literature on the effects of estrogens in modulation of antioxidant systems, in both sexes, and in different in vivo and in vitro models, we suggest,...
متن کاملPlants of Zimbabwe used as anti-fertility agents.
Ethnomedicine has gained a lot of recognition in post-independence Zimbabwe and yet little research on anti-fertility medicines has been done. Information on plants used as anti-fertility medicines was obtained by interviewing women, men, traditional healers and traditional midwives in urban Harare and surrounding rural areas of Mvurwi, Seke and Chiweshe. The use of 31 species belonging to 17 f...
متن کاملImportance of estrogens in human males' fertility and bone pathophysiology.
Since estrogens play a crucial role in several processes such as embryo implantation and fetal development it has been thought that mutation of the estrogenreceptor (ER) gene would be lethal. This hypothesis was supported by the fact that no mutations of the ER gene leading to estrogen insensitivity had been observed in mammalians. In contrast, conditions of resistance to other hormones (tri-io...
متن کاملPolysaccharides from Aloe Leaf Mucilage as Potential Immunological-based Anti-fertility Agents
Mucilaginous exudates from Aloe leaf containing polysaccharides, of which the major proportion has been reported to be composed of acetylated mannose molecules such as Acemannan and other high molecular weight polysaccharides. These polysaccharides, have been reported to elevate the Granulocyte Macrophage Colony Stimulating Factor (GMCSF) ultimately leading to the infiltration of macrophages at...
متن کاملEstrogens as endogenous genotoxic agents--DNA adducts and mutations.
Estrogens induce tumors in laboratory animals and have been associated with breast and uterine cancers in humans. In relation to the role of estrogens in the induction of cancer, we examine formation of DNA adducts by reactive electrophilic estrogen metabolites, formation of reactive oxygen species by estrogens and the resulting indirect DNA damage by these oxidants, and, finally, genomic and g...
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ژورنال
عنوان ژورنال: Medicinal Chemistry
سال: 2015
ISSN: 2161-0444
DOI: 10.4172/2161-0444.1000002-r