Anti-dementia acetylcholine esterase inhibitor inhibits osteoclastogenesis
نویسندگان
چکیده
منابع مشابه
Nicotinic acetylcholine receptors modulate osteoclastogenesis
BACKGROUND Our aim was to investigate the role of nicotinic acetylcholine receptors (nAChRs) in in-vitro osteoclastogenesis and in in-vivo bone homeostasis. METHODS The presence of nAChR subunits as well as the in-vitro effects of nAChR agonists were investigated by ex vivo osteoclastogenesis assays, real-time polymerase chain reaction, Western blot and flow cytometry in murine bone marrow-de...
متن کاملTheoretical Designing of Acetylcholine Esterase (AChE) Inhibitors
Alzheimer’s disease still remains as an untreatable neurological disorder with no successful treatment strategy to prevent or cure or reverse the damage. Globally, AD is 5th major cause of death. Over last three decades, accumulating evidence for Alzheimer’s suggest multiple causes, predominantly the gene make up of affected individuals are altered. Affected individuals suffer from severe loss ...
متن کاملTheoretical Designing of Acetylcholine Esterase (Ache) Inhibitors
Alzheimer’s disease still remains as an untreatable neurological disorder with no successful treatment strategy to prevent or cure or reverse the damage. Globally, AD is 5th major cause of death. Over last three decades, accumulating evidence for Alzheimer’s suggest multiple causes, predominantly the gene make up of affected individuals are altered. Affected individuals suffer from severe loss ...
متن کاملTheoretical Designing of Acetylcholine Esterase (AChE) Inhibitors
Alzheimer’s disease still remains as an untreatable neurological disorder with no successful treatment strategy to prevent or cure or reverse the damage. Globally, AD is 5th major cause of death. Over last three decades, accumulating evidence for Alzheimer’s suggest multiple causes, predominantly the gene make up of affected individuals are altered. Affected individuals suffer from severe loss ...
متن کاملEnoxacin directly inhibits osteoclastogenesis without inducing apoptosis.
Enoxacin has been identified as a small molecule inhibitor of binding between the B2-subunit of vacuolar H+-ATPase (V-ATPase) and microfilaments. It inhibits bone resorption by calcitriol-stimulated mouse marrow cultures. We hypothesized that enoxacin acts directly and specifically on osteoclasts by disrupting the interaction between plasma membrane-directed V-ATPases, which contain the osteocl...
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ژورنال
عنوان ژورنال: Bone Abstracts
سال: 2013
ISSN: 2052-1219
DOI: 10.1530/boneabs.1.pp213