Anti-CD3 mAb treatment cures PDL1−/−.NOD mice of diabetes but precipitates fatal myocarditis
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چکیده
منابع مشابه
Combination Treatment With Anti-CD20 and Oral Anti-CD3 Prevents and Reverses Autoimmune Diabetes
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease, although B cells also play an important role in T1D development. Both T cell- and B cell-directed immunotherapies have shown efficacy in the prevention and reversal of T1D. However, whether the combined strategy of targeting both T and B cells could further improve therapeutic efficacy remains to be explored. We show that combined t...
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ژورنال
عنوان ژورنال: Clinical Immunology
سال: 2011
ISSN: 1521-6616
DOI: 10.1016/j.clim.2011.03.011