Anti-biofilm multi drug-loaded 3D printed hearing aids

نویسندگان

چکیده

Over 5% of the world's population has disabling hearing loss, which affects approximately one third individuals over 65 years. Hearing aids are commonly used in this group, but prolonged use these devices may cause ear infections. We describe for first time, 3D printing to fabricate loaded with two antibiotics, ciprofloxacin and fluocinolone acetonide. Digital light processing was employed manufacture from polymer resins, ENG hard Flexible. The inclusion antibiotics did not affect mechanical properties aids. All multi-drug-loaded exhibited a hydrophilic surface, excellent blood compatibility anti-biofilm activity against P. aeruginosa S. aureus. (6% w/w) acetonide (0.5% sustained drug release more than weeks inhibited biofilm formation on surface bacteria growth surrounding medium. In summary, work highlights potential vat photopolymerization as versatile manufacturing approach high-fidelity patient-specific medical anti-bacterial properties.

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ژورنال

عنوان ژورنال: Materials Science and Engineering: C

سال: 2021

ISSN: ['1873-0191', '0928-4931']

DOI: https://doi.org/10.1016/j.msec.2020.111606