Anti-asthmatic effect of N-(3’,4’-dimethoxycinnamoyl) anthranilic acid (N-5’)
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چکیده
منابع مشابه
Anti-tumor effect of N-[3,4-dimethoxycinnamoyl]-anthranilic acid (tranilast) on experimental pancreatic cancer.
The anti-tumor effect of N- [3,4-dimethoxycinnamoyl] -anthranilic acid (tranilast) was examined in experimental pancreatic cancer. Proliferation of PGHAM-1 cells was inhibited by tranilast in a dose-dependent manner, showing a significant difference at a concentration of 25 microgram/ml (p<0.05). In colony formation, tranilast reduced the number of colonies at a concentration of 25 microgram/ml...
متن کاملInhibitory effect of N-(3,4-dimethoxycinnamoyl)anthranilic acid on release of SRS from alveolar macrophages in vitro.
The effects of N-(3,4-dimethoxycinnamoyl)anthranilic acid (N-5') on the release of the slow-reacting substance (SRS) by zymosan- or Ca ionophore-stimulated rat and human alveolar macrophages (AM) were examined in vitro. Disodium cromoglycate (DSCG) was used as a control. N-5' at concentrations of 10(-4)-10(-3) M significantly inhibited the release of SRS from both rat and human AM stimulated by...
متن کاملThe inhibition mechanism of histamine release by N-(3,4-dimethoxycinnamoyl) anthranilic acid.
N-(3,4-Dimethoxycinnamoyl) anthranilic acid (N-5') is an inhibitor of IgE-mediated histamine release from mast cells. To elucidate inhibition mechanism, effects of N-5' were examined under various conditions using peritoneal exudate cells and isolated mast cells of rats. N-5' inhibited histamine release induced by antigen, ionophore A23187, ATP, dextran and phospholipase A2. But the release ind...
متن کاملThe nonenzymatic preparation in solution of N-(5'-phosphoribosyl) anthranilic acid, an intermediate in tryptophan biosynthesis.
Yanofsky (1) originally proposed N-(5’-phosphoribosyl)anthranilic acid as the first intermediate after anthranilic acid in tryptophan biosynthesis in microorganisms. Evidence was subsequently found which suggested that this compound is formed enzymatically from anthranilic acid and ribosylpyrophosphate 5-phosphate (2, 3). Although the dephosphorylated form of PRA,’ N-ribosylanthranilic acid, ha...
متن کاملThe anti-allergic drug, N-(3',4'-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis.
OBJECTIVES The degradation of tryptophan by indoleamine 2,3-dioxygenase yields a number of immunomodulatory metabolites, including 3-hydroxyanthranilic acid, 3-hydroxykynurenic acid and quinolinic acid. N-(3',4'-dimethoxycinnamonyl) anthranilic acid (3,4-DAA) is a synthetic anthranilic acid derivative that has been used therapeutically in Japan for many years as an anti-allergic drug and has re...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1975
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)65554-x