Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels
نویسندگان
چکیده
منابع مشابه
Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels.
Early in mitochondria-mediated apoptosis, the mitochondrial outer membrane becomes permeable to proteins that, when released into the cytosol, initiate the execution phase of apoptosis. Proteins in the Bcl-2 family regulate this permeabilization, but the molecular composition of the mitochondrial outer membrane pore is under debate. We reported previously that at physiologically relevant levels...
متن کاملRegulation of ceramide channels by Bcl-2 family proteins.
Mitochondrial outer membrane permeabilization to proteins, an irreversible step in apoptosis by which critical proteins are released, is tightly regulated by Bcl-2 family proteins. The exact nature of the release pathway is still undefined. Ceramide is an important sphingolipid, involved in various cellular processes including apoptosis. Here we describe the structural properties of ceramide ch...
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Cells under stress activate cell survival and cell death signaling pathways. Cell death signaling frequently converges on mitochondria, a process that is controlled by the activities of pro- and anti-apoptotic B-cell lymphoma 2 (BCL-2) proteins. In this review, we summarize current knowledge on the control of neuronal survival, development and injury by anti-apoptotic BCL-2 family proteins. We ...
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Apoptosis is a morphologically distinct form of programmed cell death essential for normal development and tissue homeostasis. Aberrant regulation of this pathway is linked to multiple human diseases, including cancer, autoimmunity, neurodegenerative disorders, and diabetes. The BCL-2 family of proteins constitutes a critical control point in apoptosis residing immediately upstream of irreversi...
متن کاملCeramide Channels and the Induction of Apoptosis: Structural Insights on Channel Formation and Regulation by Bcl-2 Family Proteins
Title of Dissertation: CERAMIDE CHANNELS AND THE INDUCTION OF APOPTOSIS: STRUCTURAL INSIGHTS ON CHANNEL FORMATION AND REGULATION BY BCL-2 FAMILY PROTEINS. Meenu Nadisha Perera, Doctor of Philosophy, 2012 Directed by: Professor Marco Colombini Department of Biology A critical event in apoptosis is the release of intermembrane space proteins from mitochondria following mitochondrial outer membran...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2008
ISSN: 0021-9258
DOI: 10.1074/jbc.m706115200