Anti-angiogenic poly-L-lysine dendrimer binds heparin and neutralizes its activity
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چکیده
منابع مشابه
Anti-angiogenic poly-L-lysine dendrimer binds heparin and neutralizes its activity.
The interaction between heparin, a polyanion, and a polycationic dendrimer with a glycine core and lysine branches Gly-Lys63(NH2)64 has been investigated. Complexation was assessed by transmission electron microscopy, size and zeta potential measurements, methylene blue spectroscopy, and measuring the anti-coagulant activity of heparin in vitro and in vivo. Complete association between the hepa...
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We previously reported the development of a cellulose fiber based blood filter device containing immobilized protamine (termed protamine filter) that could be used to control both heparin- and protamine-induced complications during extracorporeal therapy. To achieve enhanced heparin adsorption on the fibers, we examined the possibility of utilizing the poly-L-lysine based amplification method t...
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The priming capacity of chromatin of fixed nuclei and chromosomes for exogenous DNA polymerase can be evaluated radioautographically by the incorporation of labeled nucleotides. It had previously been reported that acid fixation or acid treatment of alcohol-fixed tissues led to increased priming when calf thymus DNA polymerases, specific for single-stranded DNA, were used. We employed Escherich...
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ژورنال
عنوان ژورنال: Results in Pharma Sciences
سال: 2012
ISSN: 2211-2863
DOI: 10.1016/j.rinphs.2011.12.002