Anthracycline therapy and 24-hour blood-pressure profile in long-term survivors of childhood cancer

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Anthracycline therapy and 24-hour blood-pressure profile in long-term survivors of childhood cancer.

In our previous studies, a decreased blood pressure was reported in children treated by anthracycline (AC). The aim of this study was to assess the long-term effects of AC anticancer therapy in 45 subjects aged 13-22 years by repeated 24-hour Holter monitoring of blood pressure. Sixty four aged-matched subjects served as controls. The differences between mean values of systolic (SBP) and diasto...

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Renal dysfunction and elevated blood pressure in long-term childhood cancer survivors.

BACKGROUND AND OBJECTIVES Little is known about renal function and blood pressure (BP) in long-term childhood cancer survivors. This cross-sectional study evaluated prevalence of these outcomes and associated risk factors in long-term childhood cancer survivors at their first visit to a specialized outpatient clinic. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Estimated GFR; percentages of ...

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Occult cardiotoxicity in childhood cancer survivors exposed to anthracycline therapy.

BACKGROUND More than 50% of >270 000 childhood cancer survivors in the United States have been treated with anthracyclines and are therefore at risk of developing cardiotoxicity. Cardiac magnetic resonance (CMR) has demonstrated utility to detect diffuse interstitial fibrosis and changes in regional myocardial function. We hypothesized that CMR would identify occult cardiotoxicity characterized...

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The 24-hour ambulatory blood pressure profile with verapamil.

The blood pressure response in hypertensive subjects to chronic treatment with verapamil, a calcium antagonist (or, more precisely, a slow-channel inhibitor), was studied using the Oxford system for continuous monitoring of intraarterial blood pressure. Sixteen patients underwent continuous monitoring over a 48-hour period before and after at least 6 weeks of therapy (dose range 120-160 mg thre...

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ژورنال

عنوان ژورنال: Physiological Research

سال: 2010

ISSN: 1802-9973,0862-8408

DOI: 10.33549/physiolres.932006