Anthracycline-induced phospholipase A2 inhibition
نویسندگان
چکیده
منابع مشابه
Nicotine-induced inhibition of neuronal phospholipase A2.
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Administration of anthracyclines, a family of highly effective anticancer drugs, is associated with a cumulative dose-related cardiomyopathy, the etiology of which remains poorly understood. We have discovered that administration of the anthracyclines leads to a marked inhibition of membrane-associated calcium-independent phospholipase A(2) (iPLA(2)) both in vitro and in vivo. To elucidate the ...
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متن کاملChanges in phospholipid content and myocardial calcium-independent phospholipase A2 activity during chronic anthracycline administration.
Despite numerous investigations, the causes underlying anthracycline cardiomyopathy are yet to be established. We have recently reported that acute treatment with anthracyclines inhibits membrane-associated calcium-independent phospholipase A(2) (iPLA(2)) activity both in vitro and in vivo. This study presents data that iPLA(2) activity is also suppressed during chronic drug administration. Adu...
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ژورنال
عنوان ژورنال: Cardiovascular Toxicology
سال: 2007
ISSN: 1530-7905,1559-0259
DOI: 10.1007/s12012-007-0012-6