Anterior scleral canal geometry in pressurised (IOP 10) and non-pressurised (IOP 0) normal monkey eyes

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Anterior scleral canal geometry in pressurised (IOP 10) and non-pressurised (IOP 0) normal monkey eyes.

AIMS To characterise lamina cribrosa and anterior scleral canal wall architecture in pressurised (IOP 10 mm Hg) and non-pressurised (IOP 0 mm Hg) normal monkey eyes. METHODS Eight normal eyes from eight monkeys were enucleated before sacrifice and the optic nerve heads (ONH) trephined and immersion fixed in glutaraldehyde (IOP 0). Nine normal eyes from nine monkeys were perfusion fixed in sit...

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IOP-induced lamina cribrosa deformation and scleral canal expansion: independent or related?

PURPOSE To study the association between the intraocular pressure (IOP)-induced anterior-posterior lamina cribrosa deformation (LCD) and scleral canal expansion (SCE). METHODS 3D eye-specific models of the lamina and sclera of the eyes of three normal monkeys were constructed. Morphing techniques were used to produce 768 models with controlled variations in geometry and materials. Finite elem...

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Selective laser trabeculoplasty reduces mean IOP and IOP variation in normal tension glaucoma patients

PURPOSE To evaluate the effect of selective laser trabeculoplasty (SLT) in normal tension glaucoma (NTG) patients. PATIENTS AND METHODS A retrospective review was performed of NTG patients who had undergone SLT at the Duke University Eye Center between 12/2002 and 7/2005. For each eye of each patient at pre-laser and post-laser time points, the IOP measurements were summarized by mean, standa...

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Biomechanical changes in the sclera of monkey eyes exposed to chronic IOP elevations.

PURPOSE To characterize scleral biomechanics in both eyes of eight monkeys in which chronic intraocular pressure (IOP) elevation was induced in one eye. METHODS Each posterior sclera was mounted on a pressurization apparatus, IOP was elevated from 5 to 45 mm Hg while the 3D displacements of the scleral surface were measured by speckle interferometry. Finite element (FE) models of each scleral...

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Peripapillary scleral thickness in perfusion-fixed normal monkey eyes.

PURPOSE To characterize the thickness of the peripapillary sclera in perfusion-fixed normal monkey eyes so as to build accurate computational models of intraocular pressure (IOP)-related stress and strain within these tissues. METHODS Nine rhesus monkeys were perfusion fixed, each with one normal eye set to an IOP of 10 mm Hg by manometer. A 6-mm-diameter specimen containing the optic nerve h...

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ژورنال

عنوان ژورنال: British Journal of Ophthalmology

سال: 2003

ISSN: 0007-1161

DOI: 10.1136/bjo.87.10.1284