Antenatal Diagnosis of Hirschsprung Disease

Antenatal diagnosis of heart disease.

Antenatal diagnosis of genetic disease.

During the past decade, a vast methodology has been developed for the study and antenatal diagnosis of genetic disorders. The cytogenetic antenatal diagnosis of chromosome abnormalities is possible through the application of new methods for chromosome visualization in cultured amniotic fluid cells. A variety of inborn errors of metabolism may be diagnosed prenatally by the study of amniotic flu...

Hirschsprung Disease Diagnosis: Calretinin Marker Role in Determining the Presence or Absence of Ganglion Cells

Background: Hirschsprung disease is a complex genetic disorder of the enteric nervous system (ENS), often called congenital aganglionic megacolon and characterized by the absence of enteric neurons along a variable length of the intestine. The definitive diagnosis of Hirschsprung disease relies on histologic and/or histochemical staining of sections fr...

rectal biopsy for diagnosis of hirschsprung disease in constipated children

background: constipation is a common problem in children and most of them are idiopathic or functional. only a few percent of constipations may relate to hirschsprung disease (hd) and may need to rectal biopsy for diagnosis. now a day, most of these children referred to the pediatric surgeon for rectal biopsy to rule out of hd. with regard to complication, emotional effect, spending time and th...

Antenatal diagnosis of congenital heart disease