Antagonism of mivacurium block with edrophonium from various degrees of spontaneous recovery

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Edrophonium antagonism of intense mivacurium-induced neuromuscular block in children.

We have studied the time course of recovery after administration of edrophonium during intense mivacurium block in children aged 2-10 yr, using thumb acceleration in response to train-of-four (TOF) stimulation. Forty-three children receiving alfentanil, propofol, nitrous oxide, isoflurane anaesthesia and mivacurium 0.2 mg kg-1 were allocated randomly to one of three groups. Patients in group 1 ...

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Dose-response relationships for edrophonium and neostigmine antagonism of mivacurium-induced neuromuscular block.

We have studied the dose-response relationships for neostigmine and edrophonium during antagonism of neuromuscular block induced by mivacurium chloride. Sixty-four ASA group I or II adults were given mivacurium 0.15 mg kg-1 during fentanyl-thiopentone-nitrous oxide-isoflurane anaesthesia. Train-of-four stimulation (TOF) was applied to the ulnar nerve every 10 s, and the force of contraction of ...

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Recovery characteristics following antagonism of atracurium with neostigmine or edrophonium.

The evoked reversal characteristics of atracurium were studied in 21 patients using edrophonium or neostigmine and a train-of-four pattern of stimulation. Reversal of residual atracurium -induced neuromuscular blockade was significantly more rapid using edrophonium compared with neostigmine. The ratio of the fourth twitch in the train-of-four to the first twitch--the T4 ratio--was significantly...

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Recovery characteristics following antagonism of vecuronium with edrophonium, neostigmine or pyridostigmine.

Vecuronium-induced neuromuscular blocks in 42 ASA physical status I and II females were antagonized with atropine and equipotent doses of edrophonium, neostigmine and pyridostigmine. Recovery characteristics including speed of reversal, dysrhythmias and mean arterial pressure changes were studied. Edrophonium was associated with the fastest neuromuscular recovery. No clinically significant card...

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Effect of antagonism of mivacurium on recovery of extraocular muscle function.

We have measured extraocular muscle function in 41 patients who received neuromuscular block with mivacurium 0.2 mg kg-1 during anaesthesia with propofol, ketorolac, fentanyl and isoflurane in nitrous oxide and oxygen, which was antagonized at the end of surgery with neostigmine 0.05 mg kg-1 and glycopyrronium 0.01 mg kg-1 in 21 of these patients. Extraocular muscle function was measured before...

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ژورنال

عنوان ژورنال: British Journal of Anaesthesia

سال: 1995

ISSN: 0007-0912

DOI: 10.1093/bja/74.2.229