Antacids in real clinical practice

Currently, proton pump inhibitors (PPIs), H2-histamine receptor blockers (H2-blockers), antacids, and anticholinergics are used to treat acid-dependent diseases of the gastrointestinal tract. PPIs considered most effective drugs for treatment However, in real clinical practice, interest remains use antacids diseases. This is due fact that not only adsorb hydrochloric acid gastric lumen (by buffering HCl present stomach, without a significant effect on its production) reduce proteolytic activity juice (reducing/ neutralizing pepsin), but also have number other pharmacotherapeutic properties demanded by gastroenterological patient. Antacids addition antisecretory action have: 1) cytoprotective, primarily gastroprotective, action, which mediated by: a) stimulation synthesis bicarbonates prostaglandins; b) mucoprotection – an increase production protective mucus epithelial cells; c) switching growth factor concentration area erosive ulcerative defects, turn activates angiogenesis, cell proliferation local reparative regenerative processes; 2) enveloping adsorbing through chelation lysolecithin bile acids, aggressive damaging upper tract; 3) regulate gastroduodenal motility to: antispasmodic streamlining evacuation; decrease intracavitary pressure stomach duodenum; obstacles formation duodenogastric reflux. To date, combined preparations, basic composition includes magnesium hydroxide aluminum hydroxide, meet requirements non-absorbable antacids. In conclusion, authors situations, indicating today rationally prescribed antacid successfully significantly solve main tasks symptomatic therapy tract, improving quality life patients.