Anonim Şirketlerde Rekabet Yasağı (TTK m.396)
نویسندگان
چکیده
منابع مشابه
Targeting dual specificity protein kinase TTK attenuates tumorigenesis of glioblastoma
Accumulating evidence has proved that glioma stem-like cells (GSCs) are responsible for tumorigenesis, treatment resistance, and subsequent tumor recurrence in glioblastoma (GBM). In this study, we identified dual specificity protein kinase TTK (TTK) as the most up-regulated and differentially expressed kinase encoding genes in GSCs. Functionally, TTK was essential for in vitro clonogenicity an...
متن کاملDoppler echocardiographic assessment of TTK Chitra prosthetic heart valve in the mitral position.
AIMS TTK Chitra heart valve prosthesis (CHVP), a tilting disc mechanical heart valve of low cost and proven efficacy, has been in use for the last 15 years. Although various studies substantiating its long-term safety and efficacy are available, no study had assessed its echocardiographic characteristics. The purpose of this study was to determine the normal Doppler parameters of CHVP in the mi...
متن کاملEchocardiographic Profile of Normaly Functioning TTK Chitra Tilting Disc Prosthetic Valves
Background and aim of the study: TTK Chitra is a tilting disc prosthetic cardiac valve being used in India. We present the echocardiographic and Doppler evaluation of normally functioning valve in mitral and aortic positions. Methods: A total of 120 patients with 134 valves implanted in the aortic and/or mitral position were studied. All patients underwent a detailed echocardiographic and Doppl...
متن کاملScaffold-Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitors
We describe and apply a scaffold-focused virtual screen based upon scaffold trees to the mitotic kinase TTK (MPS1). Using level 1 of the scaffold tree, we perform both 2D and 3D similarity searches between a query scaffold and a level 1 scaffold library derived from a 2 million compound library; 98 compounds from 27 unique top-ranked level 1 scaffolds are selected for biochemical screening. We ...
متن کاملStable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines
Inhibition of the spindle assembly checkpoint kinase TTK causes chromosome mis-segregation and tumor cell death. However, high levels of TTK correlate with chromosomal instability (CIN), which can lead to aneuploidy. We show that treatment of tumor cells with the selective small molecule TTK inhibitor NTRC 0066-0 overrides the mitotic checkpoint, irrespective of cell line sensitivity. In stable...
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ژورنال
عنوان ژورنال: Ankara Barosu Dergisi
سال: 2018
ISSN: 1300-9885
DOI: 10.30915/abd.463965