Anoctamin 1 is Apically Expressed on Thyroid Follicular Cells and Contributes to ATP- and Calcium-Activated Iodide Efflux
نویسندگان
چکیده
منابع مشابه
Anoctamin 1 is apically expressed on thyroid follicular cells and contributes to ATP- and calcium-activated iodide efflux.
BACKGROUND/AIMS Iodide efflux from thyroid cells into the follicular lumen is essential for the synthesis of thyroid hormones, however, the pathways mediating this transport have only been partially identified. A calcium-activated pathway of iodide efflux has long been recognized, but its molecular identity unknown. Anoctamin 1 (ANO1) is a calcium-activated chloride channel (CaCC), and this stu...
متن کاملAnoctamin-1/TMEM16A is the major apical iodide channel of the thyrocyte.
Iodide is captured by thyrocytes through the Na(+)/I(-) symporter (NIS) before being released into the follicular lumen, where it is oxidized and incorporated into thyroglobulin for the production of thyroid hormones. Several reports point to pendrin as a candidate protein for iodide export from thyroid cells into the follicular lumen. Here, we show that a recently discovered Ca(2+)-activated a...
متن کاملThe calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function.
The role of calcium-activated chloride channels for renal function is unknown. By immunohistochemistry we demonstrate dominant expression of the recently identified calcium-activated chloride channels, Anoctamin 1 (Ano1, TMEM16A) in human and mouse proximal tubular epithelial (PTE) cells, with some expression in podocytes and other tubular segments. Ano1-null mice had proteinuria and numerous l...
متن کاملSyntaxin 1 is expressed in the trout saccular hair cells: RT-PCR and immunocytochemical observations
Syntaxin is one of several proteins that may be involved in the docking of synaptic vesicles, synaptic vesicle recycling, and non-synaptic membrane trafficking. Presence of syntaxin has been reported in rat auditory and vestibular end organs. In the current study, we have examined the expression of message for syntaxin 1 in hair cells of the sacculus of the rainbow trout, Oncorhynchus mykiss, w...
متن کاملSyntaxin 1 is expressed in the trout saccular hair cells: RT-PCR and immunocytochemical observations
Syntaxin is one of several proteins that may be involved in the docking of synaptic vesicles, synaptic vesicle recycling, and non-synaptic membrane trafficking. Presence of syntaxin has been reported in rat auditory and vestibular end organs. In the current study, we have examined the expression of message for syntaxin 1 in hair cells of the sacculus of the rainbow trout, Oncorhynchus mykiss, w...
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ژورنال
عنوان ژورنال: Cellular Physiology and Biochemistry
سال: 2014
ISSN: 1015-8987,1421-9778
DOI: 10.1159/000366313