منابع مشابه
S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptors.
The defining characteristic of a tumor cell is its ability to escape the constraints imposed by neighboring cells, invade the surrounding tissue and metastasize to distant sites. This invasive property of tumor cells is dependent on activation of proteinases at the cell surface. The serine proteinase plasmin is one of the key proteinases that participate in the pericellular proteolysis associat...
متن کاملThe Annexin A2/S100A10 System in Health and Disease: Emerging Paradigms
Since its discovery as a src kinase substrate more than three decades ago, appreciation for the physiologic functions of annexin A2 and its associated proteins has increased dramatically. With its binding partner S100A10 (p11), A2 forms a cell surface complex that regulates generation of the primary fibrinolytic protease, plasmin, and is dynamically regulated in settings of hemostasis and throm...
متن کاملRegulation of CFTR function by annexin A2-S100A10 complex in health and disease.
Annexin A2 and S100A10 proteins form a heterotetrameric complex and belong to different families of Ca(2+)-binding proteins. Annexins are non-EF-hand-type Ca(2+)-binding proteins that exhibit Ca(2+)-dependent binding to phospholipids and membranes in various tissues. They have been implicated in many Ca(2+)-regulated processes, including regulation of membrane organization, trafficking and inte...
متن کاملThe S100A10 Subunit of the Annexin A2 Heterotetramer Facilitates L2-Mediated Human Papillomavirus Infection
Mucosotropic, high-risk human papillomaviruses (HPV) are sexually transmitted viruses that are causally associated with the development of cervical cancer. The most common high-risk genotype, HPV16, is an obligatory intracellular virus that must gain entry into host epithelial cells and deliver its double stranded DNA to the nucleus. HPV capsid proteins play a vital role in these steps. Despite...
متن کاملThe p11/S100A10 Light Chain of Annexin A2 Is Dispensable for Annexin A2 Association to Endosomes and Functions in Endosomal Transport
BACKGROUND Annexin A2 is a peripheral membrane protein that belongs to the annexin family of Ca(2+) and phospholipid-binding proteins. This protein, which plays a role in membrane organization and dynamics in particular along the endocytic pathway, exists as a heterotetrameric complex, consisting of two annexin A2 molecules bound via their N-termini to a dimer of p11/S100A10 light chains. The l...
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ژورنال
عنوان ژورنال: Cell and Tissue Research
سال: 2015
ISSN: 0302-766X,1432-0878
DOI: 10.1007/s00441-015-2266-9