Animal models of Obsessive-Compulsive Disorder (OCD)

Obsessive Compulsive Disorder (OCD)

Animal models of obsessive compulsive disorder.

Obsessive-compulsive disorder (OCD) occurs with high prevalence, and the drugs used to treat OCD are limited in efficacy and have side-effect issues. The discovery of improved medicines for OCD has been hampered in part by the lack of predictive in vivo models. This unit provides a brief overview of two methods that might have such predictive utility. Marble burying and nestlet shredding are tw...

Obsessive-compulsive disorder (OCD): is this disorder under-recognized?

Obsessive-Compulsive disorder is much more common than it was initially assumed. It can be a part of a major mental illness or can occur on its own. It was found that 1-year prevalence is in the range of 0.8-2.2 % in a study. 1 There are some interesting figures on this mental disorder: 2 1 in 200 young people at any time are suffering from OCD, boys are more likely to have an onset before pube...

Current animal models of obsessive compulsive disorder: an update.

During the last 30 years there have been many attempts to develop animal models of obsessive compulsive disorder (OCD), in the hope that they may provide a route for furthering our understanding and treatment of this disorder. The present review provides the reader with an overview of the currently active animal models of OCD, their strengths and limitations, so that the reader can use the revi...

Animal models of obsessive–compulsive disorder: utility and limitations

Obsessive-compulsive disorder (OCD) is a disabling and common neuropsychiatric condition of poorly known etiology. Many attempts have been made in the last few years to develop animal models of OCD with the aim of clarifying the genetic, neurochemical, and neuroanatomical basis of the disorder, as well as of developing novel pharmacological and neurosurgical treatments that may help to improve ...