منابع مشابه
Biology of Obesity: Lessons from Animal Models of Obesity
Obesity is an epidemic problem in the world and is associated with several health problems, including diabetes, cardiovascular disease, respiratory failure, muscle weakness, and cancer. The precise molecular mechanisms by which obesity induces these health problems are not yet clear. To better understand the pathomechanisms of human disease, good animal models are essential. In this paper, we w...
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We summarize some of the most frequenthly used rodent animal models of temporal lobe epileps and the impact of chemoconvulsants on them. Temporal lobe epilepsy is the most common epilepsy in humans in which seizures spread to the neighboring cortiase and hippocampal neuron loss and other neuropathological take place. Temporal lobe epilepsy and the other form of epilepsy cannot acquired in chini...
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Epidemiological data indicate that obesity is a risk factor for asthma. These data are supported by observations in several murine models of obesity. Ob/ob, db/db, and Cpe(fat) mice each exhibit innate airway hyperresponsiveness, a characteristic feature of asthma. These mice also respond more vigorously to common asthma triggers, including ozone. Here we discuss the implications of these data ...
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Human obesity is a complex phenomenon where economic, cultural, behavioral, and biological factors intersect in the physiological space. Developing animal models that capture several elements of the many potential interactions between these factors will only increase their translational value.
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Animal modeling is a crucial necessity in clinical studies of liver diseases. Authenticity of the data which are produced using this tool under different conditions and accuracy of the analyses and assessments which would be based on such data sets is completely dependent on the adoption of a standardized methodology for analyzes and assessment of these data sets. Cirrhosis and Fibrosis are amo...
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ژورنال
عنوان ژورنال: Obesity Reviews
سال: 2007
ISSN: 1467-7881,1467-789X
DOI: 10.1111/j.1467-789x.2007.00319.x