منابع مشابه
Animal and human carcinogens.
Lewis et al. (1) state that compared to the fairly large number (> 400) of known rodent carcinogens, only a relatively small number of compounds (-20-30) have been shown to be carcinogenic in humans. From this comparison, the authors seem to infer that animal bioassay cancer findings overpredict for human carcinogens. Of course, for most animal carcinogens there are no available epidemiologic d...
متن کاملAncient DNA from Human and Animal
Research on ancient DNA (aDNA) has the potential to enable molecular biologists and archeologists to decipher certain aspects of history by direct looking into the past. However, several major problems in this field limit the applicability of aDNA studies, most importantly contamination with modern DNA and postmortem DNA degradation. In this study we extracted and analyzed aDNA obtained from ~3...
متن کاملExperimental identification of chemical carcinogens, risk evaluation, and animal-to-human correlations
Experimental methods for the identification of chemical carcinogens have been extensively developed, including animal bioassay methods, animal models for cancer induction at major organ sites, models for the study of the effects of carcinogens in cells and tissues in culture and methods for the study of molecular events (metabolic activation, binding and detoxification of carcinogens; DNA damag...
متن کاملCancerous Contradictions: The Mis-Regulation of Human Carcinogens Based on Animal Data*
predictivity by Andrew Knight, Jarrod Bailey and Jonathan Balcombe, which received the Animal Welfare Poster Award from Deutscher Tierschutzbund (the German Animal Welfare Federation) at the 5th World Congress on Alternatives and Animal Use in the Life Sciences, Berlin, 25 August 2005. Reproduced with permission from the complete paper: Knight, A., Bailey, J., Balcombe, J. (2006). Animal carcin...
متن کاملMonitoring human exposure to 2-hydroxyethylating carcinogens.
It is known that human hemoglobin contains low levels of N-terminal N-(2-hydroxyethyl)valine. Possible sources of this modified amino acid are exposure to ethylene oxide or other 2-hydroxy-ethylating agents. Although such processes are likely to occur endogenously, the exogenous contribution to the adduct formation is unclear. In order to explore the latter, we have analyzed N-(2-hydroxyethyl)v...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1999
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.107-1566684