ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives
نویسندگان
چکیده
منابع مشابه
SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis.
BACKGROUND Visceral adipose tissue is known to release greater amounts of adipokines and free fatty acids into the portal vein, being one of the most predictive factors of nonalcoholic fatty liver disease (NAFLD). Our study has the purpose to evaluate sirtuin 1 (SIRT1), adiponectin, Forkhead/winged helix (FOXO1), peroxisome proliferator-activated receptor (PPAR)gamma1-3, and PPARbeta/delta mRNA...
متن کاملReduced expression of chemerin in visceral adipose tissue associates with hepatic steatosis in patients with obesity.
OBJECTIVE This study aimed to evaluate whether circulating levels and/or visceral adipose tissue (VAT) expression of recently described adipokines associate with histopathological severity of nonalcoholic fatty liver disease (NAFLD), independent of obesity and insulin resistance. METHODS Serum levels of adiponectin, omentin, chemerin, monocyte chemoattractant protein-1, and secreted frizzled-...
متن کاملFAS and ACC dysfunction in visceral Adipose Tissue
Background and Aim: A great interest for determining the particular mechanisms underlying lipogenesis and adipogenesis has been raised among researchers in order to fight obesity. We aimed to investigate the gene expression of FAS and its role in regulation of lipogenesis and adipogenesis in visceral adipose tissues from obese and normal-weight subjects. materials and Methods: A total of.parti...
متن کاملPerspectives on the Activities of ANGPTL8/Betatrophin
Figure 1. Hydrodynamic Tail Vein Injection of Mouse ANGPTL8/Betatrophin Plasmid DNA Induces Pancreatic Beta Cell Proliferation with Significant Variability, and hBetatrophin Exists in a Large Protein Complex in Serum (A) Pancreatic beta cell proliferation rate (% Ki67/insulin) after hydrodynamic tail vein injection of GFP (n = 14mice) ormBetatrophin (n = 38mice) plasmids (p = 0.016). This figur...
متن کاملCirculating ANGPTL8/Betatrophin Is Increased in Obesity and Reduced after Exercise Training
OBJECTIVE ANGPTL8 is a liver and adipose tissue produced protein that regulates the level of triglyceride in plasma as well as glucose homeostasis. This study was designed to evaluate the level of ANGPTL8 in obese and non-obese subjects before and after exercise training. METHODS A total of 82 non-obese and 62 adult obese were enrolled in this study. Subjects underwent a three months of exerc...
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ژورنال
عنوان ژورنال: Hormone and Metabolic Research
سال: 2017
ISSN: 0018-5043,1439-4286
DOI: 10.1055/s-0043-102950