منابع مشابه
Angiotensin II type 2 receptor-bradykinin B2 receptor functional heterodimerization.
Angiotensin II type 2 (AT2R) or bradykinin B2 (B2R) receptor activation enhances NO production. Recently, we demonstrated enhancement of NO production when AT2R and B2R are simultaneously activated in vivo. However, the mechanism involved in this enhancement is unknown. Using confocal fluorescence resonance energy transfer microscopy, we report the distance between the AT2R and B2R in PC12W cel...
متن کاملRoles of angiotensin II type 2 receptor stimulation associated with selective angiotensin II type 1 receptor blockade with valsartan in the improvement of inflammation-induced vascular injury.
BACKGROUND To investigate the effect of angiotensin (Ang) II type 1 receptor (AT(1)) blocker on vascular remodeling and explore the possibility of the involvement of Ang II type 2 receptor (AT(2)) stimulation in this process, we examined the effects of the selective AT(1) blocker valsartan on the vascular injury in wild-type (Agtr2+) and AT(2)-null (Agtr2-) mice. METHODS AND RESULTS Neointima...
متن کاملInflammation-Induced Vascular Injury II Type 1 Receptor Blockade With Valsartan in the Improvement of Roles of Angiotensin II Type 2 Receptor Stimulation Associated With Selective Angiotensin
Lan Wu, Masaru Iwai, Hironori Nakagami, Zhen Li, Rui Chen, Jun Suzuki, Masahiro Akishita, Inflammation-Induced Vascular Injury II Type 1 Receptor Blockade With Valsartan in the Improvement of Roles of Angiotensin II Type 2 Receptor Stimulation Associated With Selective Angiotensin Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2001 American Heart Association, Inc. All rights reserved...
متن کاملAngiotensin II type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats.
We have demonstrated previously that pretreatment with an angiotensin II type 2 receptor (AT(2)R) agonist is neuroprotective against a subsequent stroke independent of any changes in blood pressure. Therefore, in the current study, we have examined the potential neuroprotective effect of AT(2)R stimulation initiated after stroke induction to mimic the clinical setting. Intracerebroventricular a...
متن کاملPossible inhibition of focal cerebral ischemia by angiotensin II type 2 receptor stimulation.
BACKGROUND The role of angiotensin II receptor subtypes was investigated in focal brain ischemia induced by middle cerebral artery (MCA) occlusion. METHODS AND RESULTS In Agtr2+ (wild-type) mice, MCA occlusion induced focal ischemia of approximately 20% to 30% of the total area in coronal section of the brain. The ischemic area was significantly larger in angiotensin II type 2 receptor-defici...
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ژورنال
عنوان ژورنال: Circulation
سال: 2008
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.108.784868