Angiotensin II Type 1–Receptor Activating Antibodies in Renal-Allograft Rejection

Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection.

BACKGROUND Antibodies against HLA antigens cause refractory allograft rejection with vasculopathy in some, but not all, patients. METHODS We studied 33 kidney-transplant recipients who had refractory vascular rejection. Thirteen had donor-specific anti-HLA antibodies, whereas 20 did not. Malignant hypertension was present in 16 of the patients without anti-HLA antibodies, 4 of whom had seizur...

Angiotensin II Type 1–Receptor Activating Antibodies in Renal-Allograft Rejection

Angiotensin II Type 1–Receptor Activating Antibodies in Renal-Allograft Rejection

Duska Dragun, M.D., Dominik N. Müller, Ph.D., Jan Hinrich Bräsen, M.D., Lutz Fritsche, M.D., Melina Nieminen-Kelhä, B.S., Ralf Dechend, M.D., Ulrich Kintscher, M.D., Birgit Rudolph, M.D., Johan Hoebeke, Ph.D., Diana Eckert, M.D., Istvan Mazak, M.D., Ralph Plehm, Ph.D., Constanze Schönemann, Ph.D., Thomas Unger, M.D., Klemens Budde, M.D., Hans-Hellmut Neumayer, M.D., Friedrich C. Luft, M.D., and...

Investigation of Serum Angiotensin II Type 1 Receptor Antibodies at the Time of Renal Allograft Rejection

BACKGROUND Angiotensin II type 1 receptor (AT1R) is responsible for cardiovascular effects mediated by angiotensin II. This study aimed to investigate the impact of antibodies directed against AT1R (anti-AT1R) in renal allograft rejection. METHODS We evaluated 53 patients who had biopsy-proven rejection including antibody-mediated rejection (AMR) (N=22), T-cell-mediated rejection (TCMR) (N=29...

Mechanisms of Renal Allograft Rejection

Rejection is the major cause of graft failure, and if the injury to the tubules and glomeruli is severe, the kidney may not recover. It is therefore important to diagnose acute rejection as soon as possible to institute prompt antirejection therapy. Generally, the success with which rejection can be reversed by immunosuppressive agents determines the chance of long-term success of the transplan...