Angiotensin II AT1 Receptor Blockade Ameliorates Brain Inflammation
نویسندگان
چکیده
منابع مشابه
Blockade of Central Angiotensin II AT1 Receptor Protects the Brain from Ischemia/Reperfusion Injury in Normotensive Rats
Background: Stroke is the third leading cause of invalidism and death in industrialized countries. There are conflicting reports about the effects of Angiotensin II on ischemia-reperfusion brain injuries and most data have come from chronic hypertensive rats. In this study, hypotensive and non-hypotensive doses of candesartan were used to investigate the effects of angiotensin II AT1 receptor b...
متن کاملAngiotensin II AT1 receptor blockade reverses pathological hypertrophy and inflammation in brain microvessels of spontaneously hypertensive rats.
BACKGROUND AND PURPOSE The spontaneously hypertensive rat (SHR) is vulnerable to brain ischemia and stress and exhibits a chronically stimulated brain angiotensin II system, cerebrovascular hypertrophy, and inflammation. Pretreatment with angiotensin II type 1 (AT1) receptor antagonists protects from brain ischemia and from stress and prevents the development of stress-induced gastric ulcers in...
متن کاملAngiotensin II AT1 receptor blockade abolishes brain microvascular inflammation and heat shock protein responses in hypertensive rats.
Endothelial dysfunction and inflammation enhance vulnerability to hypertensive brain damage. To explore the participation of Angiotensin II (Ang II) in the mechanism of vulnerability to cerebral ischemia during hypertension, we examined the expression of inflammatory factors and the heat shock protein (HSP) response in cerebral microvessels from spontaneously hypertensive rats and their normote...
متن کاملblockade of central angiotensin ii at1 receptor protects the brain from ischemia/reperfusion injury in normotensive rats
background: stroke is the third leading cause of invalidism and death in industrialized countries. there are conflicting reports about the effects of angiotensin ii on ischemia-reperfusion brain injuries and most data have come from chronic hypertensive rats. in this study, hypotensive and non-hypotensive doses of candesartan were used to investigate the effects of angiotensin ii at1 receptor b...
متن کاملAngiotensin II receptor blockade in normotensive subjects: A direct comparison of three AT1 receptor antagonists.
Use of angiotensin (Ang) II AT1 receptor antagonists for treatment of hypertension is rapidly increasing, yet direct comparisons of the relative efficacy of antagonists to block the renin-angiotensin system in humans are lacking. In this study, the Ang II receptor blockade induced by the recommended starting dose of 3 antagonists was evaluated in normotensive subjects in a double-blind, placebo...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2010
ISSN: 0893-133X,1740-634X
DOI: 10.1038/npp.2010.225