ANGIOTENSIN II (ANG II) PROMOTES GROWTH AND INHIBITS APOPTOSIS IN THE NEONATAL RAT KIDNEY WITH UNILATERAL URETERAL OBSTRUCTION (UUO). • 2217
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چکیده
منابع مشابه
Renin-angiotensin system and unilateral ureteral obstruction
Unilateral ureteral obstruction (UUO) is a clinical scenario that leads to obstructive nephropathy. UUO alters the expression of many mediators in the ipsilateral kidney. Renin-angiotensin system (RAS) is involved in UUO. Angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7) as the main arms of RAS influence kidney function which may alter by UUO. Ang II via Ang II receptor subtypes I (AT1R) ...
متن کاملRenal cellular response to ureteral obstruction: role of maturation and angiotensin II.
Renal angiotensin II (ANG II) is increased as a result of unilateral ureteral obstruction (UUO), and angiotensin AT2 receptors predominate over AT1 receptors in the early postnatal period. To examine the renal cellular response to 3-day UUO in the neonatal and adult rat, AT1and AT2 receptors were inhibited by losartan and PD-123319, respectively. Additional rats received exogenous ANG II, 0.5 m...
متن کاملMetformin Prevents Renal Fibrosis in Mice with Unilateral Ureteral Obstruction and Inhibits Ang II-Induced ECM Production in Renal Fibroblasts
Renal fibrosis is the final common pathway of chronic kidney disease (CKD), and no effective medication is available clinically for managing its progression. Metformin was initially developed as an anti-diabetic drug and recently gained attention for its potential in the treatment of other diseases. In this study, we investigated its effects on renal fibrosis in a mouse model of unilateral uret...
متن کاملاثر لوزارتان بر آپوپتوز در بافت کلیه، متعاقب انسداد کامل یک‌طرفه‌ی حالب در موش صحرایی
flow. Losartan is angiotensin II receptor I (AT1) antagonist and is used for treatment of congestive heart failure and hypertension. It is widely recognized that Losartan has organ protective nature and most effective for organ damage progressing. The aim of this study was to evaluate the effect of Losartan on apoptosis in renal tissue after unilateral ureteral obstruction in rat. Materials and...
متن کاملGrowth factors and apoptosis in neonatal ureteral obstruction.
Renal insufficiency as a result of congenital obstructive nephropathy is a consequence of impaired renal growth: chronic unilateral ureteral obstruction (UUO) results in greater injury to the immature kidney than to the adult kidney. The neonatal kidney responds to UUO by marked activation of the renin-angiotensin system, which contributes to severe vasoconstriction and progressive interstitial...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1996
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199604001-02242