Angiotensin-converting Enzyme Genetic Polymorphism

Angiotensin-converting Enzyme Genetic Polymorphism

Indeed, the sample size limitation is a universal bias in all of the genetic polymorphisms in heart failure and the ACE-genotype was no different. The metanalysis by Bai et al.1. with 17 different studies included 2.453 cases (i.e. heart failure patients) from all over the world with only 60.3% being white individuals. The author concluded that there was no association between ACE DD genotype a...

Angiotensin Converting Enzyme in Sarcoidosis

Angiotensin-converting enzyme genetic polymorphism: its impact on cardiac remodeling

BACKGROUND The role of angiotensin-converting enzyme genetic polymorphisms as a predictor of echocardiographic outcomes on heart failure is yet to be established. The local profile should be identified so that the impact of those genotypes on the Brazilian population could be identified. This is the first study on exclusively non-ischemic heart failure over a follow-up longer than 5 years. OB...

Genetic polymorphism of angiotensin-converting enzyme and hypertrophic cardiomyopathy risk

BACKGROUND Genetic factors in the pathogenesis of cardiomyopathies have received a lot of attention during the past 2 decades. Some studies have reported that angiotensin-converting enzyme (ACE) gene has been associated with hypertrophic cardiomyopathy (HCM). However, there have been inconsonant results among different studies. To clarify the influence of ACE on HCM, a systemic review and meta-...

The host’s angiotensin-converting enzyme polymorphism may explain epidemiological findings in COVID-19 infections

The number of victims of the COVID-19 pandemic shows important geographical differences. In this study, a number of human genetic polymorphisms were compared to the number of Covid-19 patients and Covid-19 mortality. Data from 33 countries were analyzed. Among the polymorphisms tested, the human angiotensine converting enzyme (ACE) polymorphism turned out to be a determinant factor in both prev...