Angiogenesis Is Required for Successful Bone Induction During Distraction Osteogenesis
نویسندگان
چکیده
منابع مشابه
Angiogenesis and mineralization during distraction osteogenesis.
Distraction osteogenesis is currently a standard method of bone lengthening. It is a viable method for the treatment of short extremities as well as extensive bone defects, because large amounts of bone can be regenerated in the distraction gap. Mechanical stimulation by distraction induces biological responses of skeletal regeneration that is accomplished by a cascade of biologic processes tha...
متن کاملEnhancement of bone formation during distraction osteogenesis: pediatric applications.
Delayed bone healing during distraction osteogenesis negatively affects clinical outcome. In addition to autologous bone grafting, several mechanical, chemical, biologic, and external treatment modalities may be employed to promote bone growth during distraction osteogenesis in the pediatric patient. Mechanical approaches include compressive loading of the distraction regenerate, increased freq...
متن کاملFgf-9 is required for angiogenesis and osteogenesis in long bone repair.
Bone healing requires a complex interaction of growth factors that establishes an environment for efficient bone regeneration. Among these, FGFs have been considered important for intrinsic bone-healing capacity. In this study, we analyzed the role of Fgf-9 in long bone repair. One-millimeter unicortical defects were created in tibias of Fgf-9(+/-) and wild-type mice. Histomorphometry revealed ...
متن کاملBone formation during distraction osteogenesis is dependent on both VEGFR1 and VEGFR2 signaling.
INTRODUCTION Distraction osteogenesis (DO) is characterized by the induction of highly vascularized new bone formation through an intramembranous process largely devoid of the formation of cartilage. MATERIALS AND METHODS To test the hypothesis that DO is strictly dependent on vascualrization, we inhibited vascular endothelial growth factor (VEGF) activity by antibody blockade of both recepto...
متن کاملPeriosteal Distraction Osteogenesis: An Effective Method for Bone Regeneration
The treatment of bone defects is challenging and controversial. As a new technology, periosteal distraction osteogenesis (PDO) uses the osteogenicity of periosteum, which creates an artificial space between the bone surface and periosteum to generate new bone by gradually expanding the periosteum with no need for corticotomy. Using the newly formed bone of PDO to treat bone defects is effective...
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ژورنال
عنوان ژورنال: Journal of Bone and Mineral Research
سال: 2005
ISSN: 0884-0431
DOI: 10.1359/jbmr.050301