منابع مشابه
Gene therapy for ocular angiogenesis.
Ocular neovascularization is a central feature of diabetic retinopathy and age-related macular degeneration. These conditions are the major causes of blindness in the developed world. Current treatments are of limited efficacy and associated with significant adverse effects. Characterization of the molecular and cellular events involved in angiogenesis has led to the identification of a number ...
متن کاملAdrenomedullin: angiogenesis and gene therapy.
Adrenomedullin (AM) is a potent, long-lasting vasodilator peptide that was originally isolated from human pheochromocytoma. AM signaling is of particular significance in endothelial cell biology since the peptide protects cells from apoptosis, promotes angiogenesis, and affects vascular tone and permeability. The angiogenic effect of AM is mediated by activation of Akt, mitogen-activated protei...
متن کاملInvited Review Adrenomedullin: angiogenesis and gene therapy
Nagaya, Noritoshi, Hidezo Mori, Shinsuke Murakami, Kenji Kangawa, and Soichiro Kitamura. Adrenomedullin: angiogenesis and gene therapy. Am J Physiol Regul Integr Comp Physiol 288: R1432–R1437, 2005; doi:10.1152/ajpregu.00662.2004.—Adrenomedullin (AM) is a potent, long-lasting vasodilator peptide that was originally isolated from human pheochromocytoma. AM signaling is of particular significance...
متن کاملImpact of SULF1 Gene on Angiogenesis
Single-gene disorders occur when mutation in a gene causing alteration of gene function while in multifactorial disorders, mutations occur in multiple genes, and these are usually coupled with environmental causes. In addition, in a multifactorial disorder such as diabetes, the complication is under the influence of different genes. For example, in diabetic retinopathy many genes are involved i...
متن کاملAngiogenesis by gene therapy: a new horizon for myocardial revascularization?
The concept of therapeutic angiogenesis is based on the premise that the potential for vascular growth inherent in vascular tissue can be utilized to promote the development of new blood vessels under the influence of the appropriate growth factors. Direct application of growth factors of the fibroblast (acidic, basic fibroblast growth factor, FGF-5), endothelial (vascular endothelial growth fa...
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ژورنال
عنوان ژورنال: Circulation
سال: 1999
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.100.5.468