Angiogenesis and airway reactivity in asthmatic Brown Norway rats
نویسندگان
چکیده
منابع مشابه
Airway responses in Brown Norway rats following inhalation sensitization and challenge with trimellitic anhydride.
Trimellitic anhydride (TMA) is a cause of asthma in man. Dose-dependent TMA-specific IgE, histopathology, and airway responses after sensitization by inhalation were examined in the Brown Norway rat. Rats were exposed to 0.04, 0.4, 4, or 40 mg/m3 TMA aerosol for 10 min, once a week, over 10 weeks. All lower exposures were, subsequently, rechallenged to 40 mg/m3 TMA aerosol. All rats received a ...
متن کاملRepeated allergen exposure of sensitized Brown-Norway rats induces airway cell DNA synthesis and remodelling.
Chronic inflammation in asthmatic airways can lead to characteristic airway smooth muscle (ASM) thickening and pathological changes within the airway wall. This study assessed the effect of repeated allergen exposure on ASM and epithelial cell deoxyribonucleic acid (DNA) synthesis, cell recruitment and airway wall pathology. Brown-Norway rats were sensitized and then exposed to ovalbumin or sal...
متن کاملAirway remodeling in allergen-challenged Brown Norway rats: distribution of proteoglycans.
Proteoglycans (PG) have important effects on the mechanical properties of tissues and the phenotype of various structural cells. Little is known about changes in PG deposition in the airways in animal models of asthma. We studied changes in PG in the airway wall of Brown Norway rats sensitized to ovalbumin (OA) and exposed to repeated OA challenge. Control (Sal) animals were sensitized and chal...
متن کاملConsumption of hypoallergenic flour prevents gluten-induced airway inflammation in Brown Norway rats.
Brown Norway rats were immunized with gluten, and then fed a diet containing hypoallergenic flour or an amino acid mixture. The rats were then made to inhale a solubilized gluten to induce gluten-specific bronchial asthma. The antibody levels in the serum of rats were measured by ELISA, and cell counts were done on cytospin preparations of bronchoalveolar lavage fluid. Body weight was decreased...
متن کاملEffects of zileuton on airway smooth muscle remodeling after repeated allergen challenge in brown Norway rats.
BACKGROUND Chronic asthma is characterized by airway inflammation and remodeling. OBJECTIVE This study aimed to evaluate the effects of zileuton on bronchial hyperresponsiveness, airway inflammation and airway smooth muscle (ASM) remodeling. METHODS Two experimental groups of brown Norway rats sensitized and repeatedly challenged with aerosolized ovalbumin (OA) were given oral zileuton (OA-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Angiogenesis
سال: 2014
ISSN: 0969-6970,1573-7209
DOI: 10.1007/s10456-014-9441-6