Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division
نویسندگان
چکیده
منابع مشابه
Epithelial Cell Division: Keeping Aneuploidy Levels in Check
Aneuploidy is deleterious at the cellular and organismal level and can promote tumorigenesis. Two new studies in Drosophila imaginal discs underscore the cellular and tissue-wide mechanisms that prevent the accumulation of aneuploid cells in symmetrically dividing epithelial tissues upon changes in centrosome number.
متن کاملMeiotic-Like Division to a Aneuploidy: Chromosomal Instability (CIN), Cell-Senescence and Cancer
An understanding of cancer cell heterogeneity requires knowledge of mechanisms for somatic cell variation. For plant (galls) and animals alike, such genetic cell differences can arise from mutations, somatic crossing over, segregation mistakes and from certain viral infection. This latter route for some DNAviruses is an early virus-induced change to polyploid cells which is also increasingly be...
متن کاملAbscisic Acid increases terrestrial plant cell resistance to hydrostatic pressure.
Cells of the terrestrial plant species bromegrass (Bromus inermis L.) are not naturally adapted to withstand the hydrostatic pressures encountered in aquatic environments. However, after treatment with the natural plant growth hormone abscisic acid (75 micromolar), bromegrass cells survived a hydrostatic pressure of 101.3 megapascals, approximating the limits of ocean depth (10,860 m). The incr...
متن کاملCell-type-specific responses to chemotherapeutics in breast cancer.
Recent microarray studies have identified distinct subtypes of breast tumors that arise from different cell types and that show statistically significant differences in patient outcome. To gain insight into these differences, we identified in vitro and in vivo changes in gene expression induced by chemotherapeutics. We treated two cell lines derived from basal epithelium (immortalized human mam...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2020
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.2009506117