Aneuploidy and Aging
نویسندگان
چکیده
منابع مشابه
Aneuploidy in health, disease, and aging
Aneuploidy, an aberrant number of chromosomes, has been recognized as a feature of human malignancies for over a century, but compelling evidence for causality was largely lacking until mouse models for chromosome number instability were used. These in vivo studies have not only uncovered important new insights into the extremely complex aneuploidy-cancer relationship but also into the molecula...
متن کاملRegion- and Cell-specific Aneuploidy in Brain Aging and Neurodegeneration
Variations in genomic DNA content, or aneuploidy, are a well-recognized feature of normal human brain development. Whether changes in the levels of aneuploidy are a factor in Alzheimer's disease (AD) is less clear, as the data reported to date vary substantially in the levels of aneuploidy detected (0.7-11.5%), possibly due to methodological limitations, but also influenced by individual, regio...
متن کاملChromosome-specific accumulation of aneuploidy in the aging mouse brain.
Chromosomal aneuploidy, the gain or loss of whole chromosomes, is a hallmark of pathological conditions and a causal factor of birth defects and cancer. A number of studies indicate that aneuploid cells are present at a high frequency in the brain of mice and humans, suggesting that mosaic aneuploidies are compatible with normal brain function and prompting the question about their consequences...
متن کاملAneuploidy
The terms 'haploid' and 'diploid' that describe single (n) and double (2n) chromosome sets in cells were coined by the Polish-German botanist Eduard Strasburger and originate from the Greek terms haplóos meaning 'single' and diplóos meaning 'double'. The term 'ploidy' was subsequently derived to describe the total chromosome content of cells. Consequently, the term 'euploid' refers to a chromos...
متن کاملAutobiographical memory and aging
Autobiographical memory, or memory for personal experiences, allows individuals to define themselves and construct a meaningful life story. Current research aims to review the definition and theories of autobiographies memory and how it usually changes or abnormally in older adults. Base on studies, as we grow older autobiographical memory drops off, also semantic memory changes a little or som...
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ژورنال
عنوان ژورنال: Journal of the Anthropological Society of Nippon
سال: 1970
ISSN: 0003-5505,1884-765X
DOI: 10.1537/ase1911.78.187