منابع مشابه
Local Anesthetics Properties of Local Anesthetics
The first clinical uses of a local anesthetic agent occurred in 1884, when cocaine was employed as a topical agent for eye surgery and to produce a nerve block. These events inaugurated a new era, that of regional anesthesia. New applications were developed, including spinal, epidural, and caudal anesthesia. The search for a better local anesthetic led to chemical synthesis of a number of other...
متن کاملAnesthetics and cardioprotection
The prevalence of the cardiovascular disease significantly affects the outcome of both cardiac and non-cardiac surgery, and perioperative cardiac morbidity is one of the leading causes of death following anesthesia and surgery. The considerable incidence of myocardial infarction, congestive heart failure, myocardial ischemia, or serious dysrhythmias during the intraoperative or postoperative pe...
متن کاملChapter 11 - Local Anesthetics
QUESTIONS OF THE DAY L ocal anesthesia can be defined as loss of sensation in a discrete region of the body caused by disruption of impulse generation or propagation. Local anesthesia can be produced by various chemical and physical means. However, in routine clinical practice, local anesthesia is produced by a narrow class of compounds, and recovery is normally spontaneous, predictable, and co...
متن کاملToxicity of local anesthetics
Systemic neurotoxicity due to excessive cerebral local anesthetic blood levels is one of the most severe and most frequent adverse outcome of local anesthetic use. Toxic levels are most often produced by unintentional intravenous or intraarterial injection(1,2). Toxicity can also result from the rapid absorption of drug following perineural injection. Peak blood levels are usually obtained acco...
متن کاملAnesthetics and epigenetics
Developmental brain in humans and rodents is complex in nature and is composed of continuous alteration of neuronal proliferation, synaptogenesis, synaptic plasticity density to establish and maintain the complicated networks in the brain and central nervous system. The developing brain always being exposed to several environmental challenges including anesthetics that can significantly affect ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Lancet
سال: 1893
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(00)80339-6